[1] MARQUEZ N, SANCHO R, MACHO A, et al. Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-κB transcription factors . J Pharmacol Exp Ther, 2004, 308(3):993-1001. [2] BRASH D E, RUDOLPH J A, SIMON J A, et al. A role for sunlight in skin cancer:UV-induced p53 mutations in squamous cell carcinoma . Proc Natl Acad Sci USA, 1991, 88(22):10124-10128. [3] PRASAD N R, JEYANTHIMALA K, RAMACHANDRAN S. Caffeic acid modulates ultraviolet radiation-B induced oxidative damage in human blood lymphocytes . J Photochem Photobiol B, 2009, 95(3):196-203. [4] HOU J, FU J, ZHANG Z M, et al. Biological activities and chemical modifications of caffeic acid derivatives . Fudan Univ J Med Sci, 2011, 38(6):546-552. [5] MORI H, IWAHASHI H. Antioxidant activity of caffeic acid through a novel mechanism under UVA irradiation . J Clin Biochem Nutr, 2009, 45(1):49-55. [6] FRIEDMAN M, JURGENS H S. Effect of pH on the stability of plant phenolic compounds . J Agric Food Chem, 2000, 48(6):2101-2110. [7] BAKIR S, OZBAY M, GN R, et al. The protective role of caffeic acid phenethyl ester against streptomycin ototoxicity . Am J Otolaryngol, 2013, 34(1):16-21. [8] KHANDUJA K L, AVTI P K, KUMAR S, et al. Anti-apoptotic activity of caffeic acid, ellagic acid and ferulic acid in normal human peripheral blood mononuclear cells:A Bcl-2 independent mechanism . Biochim Biophys Acta, 2006, 1760(2):283-289. [9] GULCIN I. Antioxidant activity of caffeic acid (3, 4-dihydroxycinnamic acid) . Toxicology, 2006, 217(2-3):213-220. FACINO R M, CARINI M, ALDINI G, et al. Echinacoside and caffeoyl conjugates UVC-protective effect of caffeic acid protects collagen from free radical-induced degradation:A potential use of echinacea extracts in the prevention of skin photo-damage . Planta Med, 1995, 61(6):510-514. PARK J H, LEE J K, KIM H S, et al. Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice . Int Immunopharmacol, 2004, 4(3):429-436. ANWAR J, SPANEVELLO R M, THOM G, et al. Effects of caffeic acid on behavioral parameters and on the activity of acetylcholinesterase in different tissues from adult rats . Pharmacol Biochem Behav, 2012, 103(2):386-394. NIZRI E, HAMRA-AMITAY Y, SICSIC C, et al. Anti-inflammatory properties of cholinergic up-regulation:A new role for acetylcholinesterase inhibitors . Neuropharmacology, 2006, 50(5):540-547. SHIN D H, NAM J H, LEE E S, et al. Inhibition of Ca(2+) release-activated Ca(2+) channel (CRAC) by curcumin and caffeic acid phenethyl ester (CAPE) via electrophilic addition to a cysteine residue of orai1 . Biochem Biophys Res Commun, 2012, 428(1):56-61. GAMARO G D, SUYENAGA E, BORSOI M, et al. Effect of rosmarinic and caffeic acids on inflammatory and nociception process in rats . ISRN Pharmacol, 2011, 2011:451682. ORBAN Z, MITSIADES N, BURKE T R J R, et al. Caffeic acid phenethylester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppress acute inflammation . Neuroimmunomodulation, 2000, 7(2):99-105. JUMAN S, YASUI N, OKUDA H, et al. Caffeic acid phenethyl ester suppresses the production of adipocytokines, leptin, tumor necrosis factor -alpha and resistin, during differentiation to adipocytes in 3T3-L1 cells . Biol Pharm Bull, 2011, 34(4):490-494. JUMAN S, YASUI N, IKEDA K, et al. Caffeic acid phenethyl ester suppresses the production of pro-inflammatory cytokines in hypertrophic adipocytes through lipopolysaccharide-stimulated macrophages . Biol Pharm Bull, 2012, 35(11):1941-1946. MEHROTRA A, SHANBHAG R, CHAMALLAMUDI M R, et al. Ameliorative effect of caffeic acid against inflammatory pain in rodents . Eur J Pharmacol, 2011, 666(1-3):80-86. LIU F, XIAO D H. Compound caffeic acid tablet combined with prednisone and azathioprine in the treatment of chronic refractory idiopathic thrombocytopenic purpura:A clinical observation . J Huaihai Med, 2011, 29(5):337-339. ZHANG Q, HU Z, WANG F, et al.Preventive and therapeutical effects of caffeic acid on leucopenia and thrombocytopenia and MPV change induced by cytosine arabinoside in mice .Chin J Clin Pharmacol Ther(中国临床药理学与治疗学),2008, 13(5):508-511. CAVALIERE V, PAPADEMETRIO D L, LORENZETTI M, et al. Caffeic acid phenylethyl ester and MG-132 have apoptotic and antiproliferative effects on leukemic cells but not on normal mononuclear cells . Transl Oncol, 2009, 2(1):46-58. ONORI P, DEMORROW S, GAUDIO E, et al. Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-κB and induction of apoptosis . Int J Cancer, 2009, 125(3):565-576. SHVARZBEYN J, HULEIHEL M. Effect of propolis and caffeic acid phenethyl ester (CAPE) on NFκB activation by HTLV-1 tax . Antiviral Res, 2011, 90(3):108-115. IRAZ M, FADILLIOGLU E, TASDEMIR S, et al. Role of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (CAPE) . Cardiovasc Toxicol, 2005, 5(4):391-396. PARK J B. 5-Caffeoylquinic acid and caffeic acid orally administered suppress P-selectin expression on mouse platelets . J Nutr Biochem, 2009, 20(10):800-805. HSIAO G, LEE J J, LIN K H, et al. Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human plateletsIn vitro and in vivo studies . Cardiovasc Res, 2007, 75(4):782-792. CHAO P C, HSU C C, YIN M C. Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice . Nutr Metab, 2009, 6:33. HO H C, CHANG H C, TING C T, et al. Caffeic acid phenethyl ester inhibits proliferation and migration, and induces apoptosis in platelet-derived growth factor-BB-stimulated human coronary smooth muscle cells . J Vasc Res, 2012, 49(1):24-32. KUMARAN K S, PRINCE P S. Protective effect of coffee acid on cardiac markers and lipid peroxide metabolism in cardiotoxic ratsAn in vivo and in vitro study . Metabolism, 2010, 59(8):1172-1180. KUMARAN K S, PRINCE P S. Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage . Cell Stress and Chaperones, 2010, 15(6):791-806. BRAMLETT H M, DIETRICH W D. Pathophysiology of cerebral ischemia and brain traumaSimilarities and differences . J Cereb Blood Flow Metab, 2004, 24(2):133-150. ZHANG L, ZHANG W P, CHEN K D, et al. Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury . Life Sci, 2007, 80(6):530-537. TSAI S J, CHAO C Y, YIN M C. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice . Eur J Pharmacol, 2011, 670(2-3):441-447. CAMPOS F M, COUTO J A, HOGG T A. Influence of phenolic acids on growth and inactivation of oenococcus oeni and lactobacillus hilgardii . J Appl Microbiol, 2003, 94(2):167-174. WEN A M, DELAQUIS P, STANICH K, et al. Antilisterial activity of selected phenolic acids . Food Microbiol, 2003, 20(3):305-311. CANILLAC N, MOUREY A. Effects of several environmental factors on the anti-Listeria monocytogenes activity of an essential oil of picea excelsa . Int J Food Microbiol, 2004, 92(1):95-103. CHIRINO Y I, PEDRAZA-CHAVERRI J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity . Exp Toxicol Pathol, 2009, 61(3):223-242. AJITH T A, USHA S, NIVITHA V. Ascorbic acid and alpha-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in miceA comparative study . Clin Chim Acta, 2007, 375(1-2):82-86. ARIVARASU N A, FATIMA S, MAHMOOD R. Effect of cisplatin on brush border membrane enzymes and anti-oxidant system of rat intestine . Life Sci, 2007, 81(5):393-398. ARIVARASU N A, PRIYAMVADA S, MAHMOOD R. Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine . Exp Toxicol Pathol, 2013, 65(1-2):21-25. KART A, CIGREMIS Y, KARAMAN M, et al. Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit . Exp Toxicol Pathol, 2010, 62(1):45-52. OGHAN F, APUHAN T, YILMAZ F. Ototoxicity caused by topical administration of gentamicin versus tobramycin in rabbits . Int J Pediatr Otorhinolaryngol, 2011, 75(7):915-918. XIE J, TALASKA A E, SCHACHT J. New developments in aminoglycoside therapy and ototoxicity . Hear Res, 2011, 281(1-2):28-37. CHEN F Q, SCHACHT J, SHA S H. Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea . J Neurochem, 2009, 108 (5):1226-1236. SONG H S, PARK T W, SOHN U D, et al. The effect of caffeic acid on wound healing in skin-incised mice . Korean J Physiol Pharmacol, 2008, 12(6):343-347.